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  1. Review

    The epidermal growth factor receptor (EGRF) in lung cancer

    In the last decade, important advances have been made in understanding of cancer biology, particularly non-small-cell lung cancer (NSCLC) with the discovery of oncogenic drivers of the disease. The epidermal g...

    Enric Carcereny, Teresa Morán, Laia Capdevila, Sara Cros, Laia Vilà, Maria de los Llanos Gil, Jordi Remón and Rafael Rosell

    Translational Respiratory Medicine 2015 3:1

    Published on: 24 February 2015

  2. Research

    Expression of transcript factors SALL4 and OCT4 in a subset of non-small cell lung carcinomas (NSCLC)

    SALL4 and OCT4 are transcription factors and play essential roles in stem cell development and oncogenesis. However, the expression of these transcription factors has not been well studied in lung cancers. In ...

    Erika Rodriguez, Li Chen, Ming-Hui Ao, Susan Geddes, Ed Gabrielson, Frederic Askin, Hui Zhang and Qing Kay Li

    Translational Respiratory Medicine 2014 2:10

    Published on: 2 October 2014

  3. Research

    Serial pulmonary function tests to diagnose COPD in chronic heart failure

    It is unknown whether serial pulmonary function tests are necessary for the correct diagnosis of chronic obstructive pulmonary disease (COPD) in patients with stable non-congested chronic heart failure (CHF). ...

    Armine G Minasian, Frank JJ van den Elshout, PN Richard Dekhuijzen, Petra JE Vos, Frank F Willems, Paul JPC van den Bergh and Yvonne F Heijdra

    Translational Respiratory Medicine 2014 2:12

    Published on: 25 September 2014

  4. Research

    Performance of standard procedures in detection of EGFR mutations in daily practice in advanced NSCLC patients selected according to the ESMO guideline: a large Caucasian cohort study

    ESMO consensus recommends EGFR mutation testing in never/former light smokers (<15 pack-years) or patients with non-squamous NSCLC. The aim of this work was to determine the frequency and clinical predictors o...

    Inge Hantson, Christophe Dooms, Eric Verbeken, Peter Vandenberghe, Liesbet Vliegen, Tania Roskams, Sara Vander Borght, Kris Nackaerts, Isabelle Wauters and Johan Vansteenkiste

    Translational Respiratory Medicine 2014 2:9

    Published on: 11 September 2014

  5. Research

    Response of airway epithelial cells to double-stranded RNA in an allergic environment

    Respiratory viral infections are the most common trigger of acute exacerbations in patients with allergic asthma. The anti-viral response of airway epithelial cells (AEC) may be impaired in asthmatics, while c...

    Cristan Herbert, Qing-Xiang Zeng, Ramesh Shanmugasundaram, Linda Garthwaite, Brian G Oliver and Rakesh K Kumar

    Translational Respiratory Medicine 2014 2:11

    Published on: 11 September 2014

  6. Perspective

    Looking for the elusive lung stem cell niche

    This discourse contains three perspectives on various aspects of Stem Cell Biology and tools available to study and translate into Regenerative Medicine. The lung incessantly faces onslaught of the environment...

    Ena Ray Banerjee

    Translational Respiratory Medicine 2014 2:7

    Published on: 3 April 2014

  7. Review

    Secretion properties, clearance, and therapy in airway disease

    Chronic airway diseases like cystic fibrosis, chronic bronchitis, asthma, diffuse panbronchiolitis, and bronchiectasis are all associated with chronic inflammation. The airway mucosa responds to infection and ...

    Bruce K Rubin

    Translational Respiratory Medicine 2014 2:6

    Published on: 10 March 2014

  8. Research

    Epidemiology of bronchial asthma and asthma control assessment in Henan Province, China

    Prevalence of bronchial asthma, asthma treatment assessment, and estimation of the control level among asthma patients in Henan Province, China are reported in this paper.

    Wenping Zhang, Xianliang Chen, Lijun Ma, Jizhen Wu, Limin Zhao, Hongyan Kuang, Taibo Huang, Jianjian Cheng, Luoxian Zhang, Yong Qi, Beibei Sun and Hongyan Niu

    Translational Respiratory Medicine 2014 2:5

    Published on: 5 March 2014

  9. Review

    Diagnosis and management of interstitial lung disease

    The complex tasks of making a confident diagnosis of a specific form of interstitial lung disease (ILD) and formulating a patient-centered, personalized management plan in an attempt to achieve remission or st...

    Keith C Meyer

    Translational Respiratory Medicine 2014 2:4

    Published on: 13 February 2014

  10. Review

    Acute lung injury and the role of histones

    Acute respiratory distress syndrome (ARDS) in humans involves ≥ 200,000 individuals in the United States, and has a mortality rate (40%) for which no specific drug has been approved for use in humans. We have ...

    Peter A Ward and Jamison J Grailer

    Translational Respiratory Medicine 2014 2:1

    Published on: 3 January 2014

  11. Review

    Pulmonary vascular remodeling and right heart failure in pulmonary hypertension: future role of positron emission tomography in decoding the enigma

    Whereas the insights into the cellular and molecular mechanisms of pulmonary arterial hypertension (PAH) and associated right heart failure have increased in recent years, there is a lack of clinical tools to ...

    Hendrik J Harms, Mariëlle C van de Veerdonk, Adriaan A Lammertsma, Anton Vonk Noordegraaf and Harm Jan Bogaard

    Translational Respiratory Medicine 2013 1:16

    Published on: 11 December 2013

  12. Review

    Role of WWOX and NF-κB in lung cancer progression

    It is generally agreed that the pro-inflammatory, pro-survival transcription factor NF-κB is a tumor promoter. Tumor necrosis factor alpha (TNF-α or TNF) mediates NF-κB activation. Tumor suppressor WWOX (FOR o...

    Szu-Jung Chen, Shenq-Shyang Huang and Nan-Shan Chang

    Translational Respiratory Medicine 2013 1:15

    Published on: 14 November 2013

  13. Research

    Standardization developments for large scale biobanks in smoking related diseases - a model system for blood sample processing and storage

    Biobank samples stored in biobanks give researchers and respiratory healthcare institutions access to datasets of analytes valuable for both diagnostic and research practices. The usefulness of these samples i...

    Johan Malm, Thomas E Fehniger, Pia Danmyr, Ákos Végvári, Charlotte Welinder, Henrik Lindberg, Paul Upton, Stephanie Carter, Roger Appelqvist, Karin Sjödin, Elisabet Wieslander, Magnus Dahlbäck, Melinda Rezeli, David Erlinge and György Marko-Varga

    Translational Respiratory Medicine 2013 1:14

    Published on: 30 August 2013

  14. Review

    Bacteria in COPD; their potential role and treatment

    The role of bacterial infection in chronic obstructive pulmonary disease (COPD) and how it should be treated has been an ongoing source of controversy. For many years bacterial infection has not been thought t...

    Paul T King, Martin MacDonald and Philip G Bardin

    Translational Respiratory Medicine 2013 1:13

    Published on: 30 August 2013

  15. Short report

    Sputum matrix metalloproteinase-9 is associated with the degree of emphysema on computed tomography in COPD

    Matrix-metalloproteinase (MMP)-9 has been implicated in the pathogenesis of COPD, although its link to disease severity is unclear. The purpose of the study was to examine the relationship between disease seve...

    Rekha Chaudhuri, Charles McSharry, Mark Spears, Jeffrey Brady, Christal Grierson, C Martina Messow, Gino Miele, Karl Nocka, William MacNee, Martin Connell, John T Murchison, Michael Sproule, Omar Hilmi, Douglas K Miller and Neil C Thomson

    Translational Respiratory Medicine 2013 1:11

    Published on: 6 June 2013

  16. Review

    The acute respiratory distress syndrome in 2013

    Acute lung injury and the acute respiratory distress syndrome are major causes of morbidity and mortality in critically ill patients. This review focuses on new developments in definitions, epidemiology, clini...

    Michael A Matthay, Yuanlin Song, Chunxue Bai and Kirk D Jones

    Translational Respiratory Medicine 2013 1:10

    Published on: 17 May 2013

  17. Editorial

    The need for translational research in respiratory medicine

    Medical advances have failed to arrest the growing morbidity and mortality from lung diseases. COPD, lung cancer and pulmonary infections remain leading causes of death. More than any other time in human histo...

    YC Gary Lee and Grant W Waterer

    Translational Respiratory Medicine 2013 1:9

    Published on: 19 April 2013

  18. Review

    Oncogenic driver mutations in lung cancer

    Lung cancer is a heterogeneous and complex disease. Genomic and transcriptomic profiling of lung cancer not only further our knowledge about cancer initiation and progression, but could also provide guidance o...

    Susan Y Luo and David CL Lam

    Translational Respiratory Medicine 2013 1:6

    Published on: 8 March 2013

  19. Perspective

    Self-aggregating TIAF1 in lung cancer progression

    Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals. The aggregati...

    Qunying Hong, Li-Jin Hsu, Pei-Yi Chou, Ying-Tsen Chou, Chen-Yu Lu, Yu-An Chen and Nan-Shan Chang

    Translational Respiratory Medicine 2013 1:5

    Published on: 28 February 2013

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