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Table 3 Some dysregulated genes in the Caucasian American patients are negatively associated with potential regulating miRNAs

From: MicroRNAs implicated in dysregulation of gene expression following human lung transplantation

Gene class Target gene Gene title microRNA p (miRanda) a p (t-test) b p (linear regression) c r 2(linear regression) d
down-regulated TCF4 transcription factor 4 hsa-miR-299-3p 0.000031 0.012 0.035 0.11
LRRC8B leucine rich repeat containing 8 family, member B hsa-miR-29b-1* 0.000056 0.019 0.0057 0.20
C14orf2 chromosome 14 open reading frame 2 hsa-miR-34a 0.000058 0.0001 0.042 0.11
FUT8 fucosyltransferase 8 hsa-miR-34a 0.0000003 0.0001 0.0084 0.17
C14orf135 chromosome 14 open reading frame 135 hsa-miR-451 0.0000086 0.0064 0.011 0.16
ATR ataxia telangiectasia and Rad3 related hsa-miR-519e 0.0000075 0.0031 0.0046 0.19
PYHIN1 pyrin and HIN domain family, member 1 hsa-miR-519e 0.000091 0.0031 0.0074 0.17
TCF4 transcription factor 4 hsa-miR-629 0.0000071 0.022 0.045 0.12
up-regulated CA1 carbonic anhydrase I hsa-miR-590-5p 0.000052 0.00067 NS  
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa-miR-381 0.000021 0.0012 0.023 0.13
NFIL3 nuclear factor, interleukin 3 regulated hsa-miR-374a 0.000046 0.011 NS  
DOCK4 dedicator of cytokinesis 4 hsa-miR-28-5p 0.000095 0.012 NS  
PLK2 polo-like kinase 2 hsa-miR-126 0.000055 0.025 NS  
PLK2 polo-like kinase 2 hsa-miR-27b 0.000000088 0.033 NS  
  1. a: p-values from the miRanda algorithm; b: p-values by comparing miRNA expression levels between patients and normal controls; c: p-values from linear regression tests on the relationships between miRNAs and target genes; NS, not significant; d: correlation coefficients from the linear regression tests.