MicroRNAs implicated in dysregulation of gene expression following human lung transplantation

Translational Respiratory Medicine

Table 3 Some dysregulated genes in the Caucasian American patients are negatively associated with potential regulating miRNAs

Gene class	Target gene	Gene title	microRNA	p (miRanda) ^a	p (t-test) ^b	p (linear regression) ^c	r ²(linear regression) ^d
down-regulated	TCF4	transcription factor 4	hsa-miR-299-3p	0.000031	0.012	0.035	0.11
	LRRC8B	leucine rich repeat containing 8 family, member B	hsa-miR-29b-1*	0.000056	0.019	0.0057	0.20
	C14orf2	chromosome 14 open reading frame 2	hsa-miR-34a	0.000058	0.0001	0.042	0.11
	FUT8	fucosyltransferase 8	hsa-miR-34a	0.0000003	0.0001	0.0084	0.17
	C14orf135	chromosome 14 open reading frame 135	hsa-miR-451	0.0000086	0.0064	0.011	0.16
	ATR	ataxia telangiectasia and Rad3 related	hsa-miR-519e	0.0000075	0.0031	0.0046	0.19
	PYHIN1	pyrin and HIN domain family, member 1	hsa-miR-519e	0.000091	0.0031	0.0074	0.17
	TCF4	transcription factor 4	hsa-miR-629	0.0000071	0.022	0.045	0.12
up-regulated	CA1	carbonic anhydrase I	hsa-miR-590-5p	0.000052	0.00067	NS
	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	hsa-miR-381	0.000021	0.0012	0.023	0.13
	NFIL3	nuclear factor, interleukin 3 regulated	hsa-miR-374a	0.000046	0.011	NS
	DOCK4	dedicator of cytokinesis 4	hsa-miR-28-5p	0.000095	0.012	NS
	PLK2	polo-like kinase 2	hsa-miR-126	0.000055	0.025	NS
	PLK2	polo-like kinase 2	hsa-miR-27b	0.000000088	0.033	NS

^a: p-values from the miRanda algorithm; ^b: p-values by comparing miRNA expression levels between patients and normal controls; ^c: p-values from linear regression tests on the relationships between miRNAs and target genes; NS, not significant; ^d: correlation coefficients from the linear regression tests.