Skip to main content

Table 1 Clinical advantages and disadvantages of 18 F-FDG PET scanning in PAH

From: Pulmonary vascular remodeling and right heart failure in pulmonary hypertension: future role of positron emission tomography in decoding the enigma

Advantages • Commonly available in many hospitals
  • Easy to manufacture and easy to transport
  • Mechanisms which predict an altered tracer activity in PAH have been relatively well studied
Disadvantages • No consensus exists on appropriate patient preparation prior to imaging (e.g. overnight fasting and glucose loading), leading to inconsistencies in results between centers
  • Lung and right ventricular 18F-FDG uptake does not correlate with disease severity or survival
  • Lung and right ventricular 18F-FDG uptake rapidly normalize upon PAH treatment, questioning the utility of 18F-FDG PET in the follow-up of patients
  • Corrections for lung density have not been performed
  • Increased FDG uptake in the heart could either reflect an increase in
  • After load or a direct, after load-independent, change in energy metabolism. It is not possible to determine the relative contributions of both processes