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Table 2 Liver and renal function evaluation following repeated i.p. injection in tumor-xenografted mice

From: A linear polyethylenimine mediated siRNA-based therapy targeting human epidermal growth factor receptor in SPC-A1 xenograft mice

Group ALT (IU/L) AST(IU/L) Urea (mmol/L) Cr (μmol/L)
5% GS 58.33±11.38 188.17±39.75 9.73±0.97 48.43±2.48
LPEI/siRNA-NEG 55.00±11.03 184.67±62.24 10.45±0.68 47.70±3.61
LPEI/siRNA-EGFR 53.83±13.47 178.33±53.41 10.35±1.04 46.87±7.55
  1. Data presented as means±s.d. of numbers obtained from 6 animals in each group.