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Table 2 Liver and renal function evaluation following repeated i.p. injection in tumor-xenografted mice

From: A linear polyethylenimine mediated siRNA-based therapy targeting human epidermal growth factor receptor in SPC-A1 xenograft mice

Group

ALT (IU/L)

AST(IU/L)

Urea (mmol/L)

Cr (μmol/L)

5% GS

58.33±11.38

188.17±39.75

9.73±0.97

48.43±2.48

LPEI/siRNA-NEG

55.00±11.03

184.67±62.24

10.45±0.68

47.70±3.61

LPEI/siRNA-EGFR

53.83±13.47

178.33±53.41

10.35±1.04

46.87±7.55

  1. Data presented as means±s.d. of numbers obtained from 6 animals in each group.