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Table 1 Predicted prevalence of severe and moderately severe BHR with changes in population BHR [Based on data from reference [14]]

From: A half doubling dose change in bronchial hyperresponsiveness in a population represents an important difference

Doubling dose worsening in population BHR

Change in Prevalence Rate ratio (95% CI)

Prevalence of moderately severe BHR, % (95% CI)

Prevalence of severe BHR, % (95% CI)

Baseline

-

41.2

6.6

0.25

1.15 (1.12-1.17)

47.3 (46.3-48.1)

7.6 (7.4-7.7)

0.5

1.31 (1.26-1.36)

54.2 (52.1-56.2)

8.7 (8.3-9.0)

0.75

1.51 (1.42-1.59)

62.2 (58.6-65.6)

10.0 (9.4-10.5)

1.0

1.73 (1.60-1.86)

71.4 (65.9-76.6)

11.4 (10.6-12.3)