Figure 6
From: The expanding role of aerosols in systemic drug delivery, gene therapy and vaccination: an update
The PuffHaler® (Aktiv-Dry, LLC, Boulder, CO, USA) (A) and the Solovent® (Becton, Dickinson and Company, Franklin Lakes, NJ, USA) (B) are two new devices that are being developed to deliver measles vaccine as a dry powder to children and infants in developing countries. When the PuffHaler squeeze bulb is compressed, the silicone rubber burst-valve pops open. The air rushes into the disperser through the powder in an aluminum foil blister and the aerosol cloud fills a collapsed plastic bag reservoir. The aerosol-filled bag is detached and affixed to a facemask from which the subject breathes for 30 s to become vaccinated (Puff-mask). The syringe of the BD Solovent device is used to pressurize the capsule containing the powder vaccine. As the pressure rises, the thin films sealing the capsule rupture, and the powder is expelled and captured in the disposable spacer for delivery through a silicone facemask (Sol-mask) (from Reference [76] with Permission).