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Table 4 Correlation between TTF-1 immunohistochemistry and presence of EGFR activating mutation

From: Performance of standard procedures in detection of EGFR mutations in daily practice in advanced NSCLC patients selected according to the ESMO guideline: a large Caucasian cohort study

Series EGFR mut + (N) EGFR mut- (N)  
Vincenten et al. [20]    NPV
TTF-1 + 105 403 96%
TTF-1 - 9 228  
Leary et al. [12]    NPV
TTF-1 + 15 40 100%
TTF-1 - 0 15  
This series    NPV
TTF-1 + 29 140 98%
TTF-1 - 1 43  
Pooled results    NPV
TTF- 1 + 149 583 97%
TTF-1 - 10 286  
  1. EGFR mut+: presence of activating EGFR mutation; N: number; TTF-1: thyroid transcription factor 1; NPV: negative predictive value.