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Translational Respiratory Medicine

Table 4 Correlation between TTF-1 immunohistochemistry and presence of EGFR activating mutation

From: Performance of standard procedures in detection of EGFR mutations in daily practice in advanced NSCLC patients selected according to the ESMO guideline: a large Caucasian cohort study

Series

EGFR mut + (N)

EGFR mut- (N)

 

Vincenten et al. [20]

  

NPV

TTF-1 +

105

403

96%

TTF-1 -

9

228

 

Leary et al. [12]

  

NPV

TTF-1 +

15

40

100%

TTF-1 -

0

15

 

This series

  

NPV

TTF-1 +

29

140

98%

TTF-1 -

1

43

 

Pooled results

  

NPV

TTF- 1 +

149

583

97%

TTF-1 -

10

286

 
  1. EGFR mut+: presence of activating EGFR mutation; N: number; TTF-1: thyroid transcription factor 1; NPV: negative predictive value.
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