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Translational Respiratory Medicine

Table 1 Relative expression by MLE-12 cells of mRNA for chemokine, cytokine and interferon-stimulated genes

From: Response of airway epithelial cells to double-stranded RNA in an allergic environment

 

Medium + Poly I:C

Th2 pre-treatment + Poly I:C

Cxcl1

2.3 ± 0.3

2.1 ± 0.4

Cxcl9

99.0 ± 27.7

178.9 ± 52.7+

Cxcl10

46.2 ± 29.8

210.5 ± 61.0*

Cxcl11

8.6 ± 2.2

61.2 ± 10.8**

Ccl5

18.7 ± 2.0

26.8 ± 10.3

Il6

1.0 ± 0.4

2.1 ± 0.2+

Il33

2.3 ± 0.3

1.2 ± 0.2*

Tslp

0.5 ± 0.2

0.9 ± 0.4

Ddx58

1.2 ± 0.4

1.9 ± 0.7

Ddx60

3.5 ± 0.8

5.4 ± 1.2

Ifih1

2.8 ± 0.7

3.5 ± 1.7

Oasl1

10.4 ± 3.1

9.6 ± 3.8

Stat1

3.2 ± 1.9

139.8 ± 30.0**

Stat2

1.2 ± 0.5

1.9 ± 0.8

Ifit1

4.3 ± 0.8

20.4 ± 7.2*

Ifitm3

1.0 ± 0.5

5.6 ± 1.3*

  1. MLE-12 cells stimulated with poly I:C for 4 hours following culture for 48 hours in either medium alone or medium containing IL-4 and IL-13. mRNA expression shown as stimulation ratio (mean ± s.e.m.) relative to cells cultured in medium alone. + 0.05 < p < 0.1; *p < 0.05; **p < 0.01 by ratio paired t-test, n = 5 separate experiments.
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