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Translational Respiratory Medicine
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  1. In the last decade, important advances have been made in understanding of cancer biology, particularly non-small-cell lung cancer (NSCLC) with the discovery of oncogenic drivers of the disease. The epidermal g...

    Authors: Enric Carcereny, Teresa Morán, Laia Capdevila, Sara Cros, Laia Vilà, Maria de los Llanos Gil, Jordi Remón and Rafael Rosell

    Citation: Translational Respiratory Medicine 2015 3:1

    Content type: Review

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  2. SALL4 and OCT4 are transcription factors and play essential roles in stem cell development and oncogenesis. However, the expression of these transcription factors has not been well studied in lung cancers. In ...

    Authors: Erika Rodriguez, Li Chen, Ming-Hui Ao, Susan Geddes, Ed Gabrielson, Frederic Askin, Hui Zhang and Qing Kay Li

    Citation: Translational Respiratory Medicine 2014 2:10

    Content type: Research

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  3. It is unknown whether serial pulmonary function tests are necessary for the correct diagnosis of chronic obstructive pulmonary disease (COPD) in patients with stable non-congested chronic heart failure (CHF). ...

    Authors: Armine G Minasian, Frank JJ van den Elshout, PN Richard Dekhuijzen, Petra JE Vos, Frank F Willems, Paul JPC van den Bergh and Yvonne F Heijdra

    Citation: Translational Respiratory Medicine 2014 2:12

    Content type: Research

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  4. Respiratory viral infections are the most common trigger of acute exacerbations in patients with allergic asthma. The anti-viral response of airway epithelial cells (AEC) may be impaired in asthmatics, while c...

    Authors: Cristan Herbert, Qing-Xiang Zeng, Ramesh Shanmugasundaram, Linda Garthwaite, Brian G Oliver and Rakesh K Kumar

    Citation: Translational Respiratory Medicine 2014 2:11

    Content type: Research

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  5. ESMO consensus recommends EGFR mutation testing in never/former light smokers (<15 pack-years) or patients with non-squamous NSCLC. The aim of this work was to determine the frequency and clinical predictors o...

    Authors: Inge Hantson, Christophe Dooms, Eric Verbeken, Peter Vandenberghe, Liesbet Vliegen, Tania Roskams, Sara Vander Borght, Kris Nackaerts, Isabelle Wauters and Johan Vansteenkiste

    Citation: Translational Respiratory Medicine 2014 2:9

    Content type: Research

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  7. This discourse contains three perspectives on various aspects of Stem Cell Biology and tools available to study and translate into Regenerative Medicine. The lung incessantly faces onslaught of the environment...

    Authors: Ena Ray Banerjee

    Citation: Translational Respiratory Medicine 2014 2:7

    Content type: Perspective

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  9. Prevalence of bronchial asthma, asthma treatment assessment, and estimation of the control level among asthma patients in Henan Province, China are reported in this paper.

    Authors: Wenping Zhang, Xianliang Chen, Lijun Ma, Jizhen Wu, Limin Zhao, Hongyan Kuang, Taibo Huang, Jianjian Cheng, Luoxian Zhang, Yong Qi, Beibei Sun and Hongyan Niu

    Citation: Translational Respiratory Medicine 2014 2:5

    Content type: Research

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  10. The complex tasks of making a confident diagnosis of a specific form of interstitial lung disease (ILD) and formulating a patient-centered, personalized management plan in an attempt to achieve remission or st...

    Authors: Keith C Meyer

    Citation: Translational Respiratory Medicine 2014 2:4

    Content type: Review

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  13. Acute respiratory distress syndrome (ARDS) in humans involves ≥ 200,000 individuals in the United States, and has a mortality rate (40%) for which no specific drug has been approved for use in humans. We have ...

    Authors: Peter A Ward and Jamison J Grailer

    Citation: Translational Respiratory Medicine 2014 2:1

    Content type: Review

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  14. Whereas the insights into the cellular and molecular mechanisms of pulmonary arterial hypertension (PAH) and associated right heart failure have increased in recent years, there is a lack of clinical tools to ...

    Authors: Hendrik J Harms, Mariëlle C van de Veerdonk, Adriaan A Lammertsma, Anton Vonk Noordegraaf and Harm Jan Bogaard

    Citation: Translational Respiratory Medicine 2013 1:16

    Content type: Review

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  15. It is generally agreed that the pro-inflammatory, pro-survival transcription factor NF-κB is a tumor promoter. Tumor necrosis factor alpha (TNF-α or TNF) mediates NF-κB activation. Tumor suppressor WWOX (FOR o...

    Authors: Szu-Jung Chen, Shenq-Shyang Huang and Nan-Shan Chang

    Citation: Translational Respiratory Medicine 2013 1:15

    Content type: Review

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  16. Biobank samples stored in biobanks give researchers and respiratory healthcare institutions access to datasets of analytes valuable for both diagnostic and research practices. The usefulness of these samples i...

    Authors: Johan Malm, Thomas E Fehniger, Pia Danmyr, Ákos Végvári, Charlotte Welinder, Henrik Lindberg, Paul Upton, Stephanie Carter, Roger Appelqvist, Karin Sjödin, Elisabet Wieslander, Magnus Dahlbäck, Melinda Rezeli, David Erlinge and György Marko-Varga

    Citation: Translational Respiratory Medicine 2013 1:14

    Content type: Research

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  17. The role of bacterial infection in chronic obstructive pulmonary disease (COPD) and how it should be treated has been an ongoing source of controversy. For many years bacterial infection has not been thought t...

    Authors: Paul T King, Martin MacDonald and Philip G Bardin

    Citation: Translational Respiratory Medicine 2013 1:13

    Content type: Review

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  18. Lung transplantation remains the only viable treatment option for the majority of patients with advanced lung diseases. However, 5-year post-transplant survival rates remain low primarily secondary to chronic ...

    Authors: Wei Zhang, Tong Zhou, Shwu-Fan Ma, Robert F Machado, Sangeeta M Bhorade and Joe GN Garcia

    Citation: Translational Respiratory Medicine 2013 1:12

    Content type: Research

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  19. Matrix-metalloproteinase (MMP)-9 has been implicated in the pathogenesis of COPD, although its link to disease severity is unclear. The purpose of the study was to examine the relationship between disease seve...

    Authors: Rekha Chaudhuri, Charles McSharry, Mark Spears, Jeffrey Brady, Christal Grierson, C Martina Messow, Gino Miele, Karl Nocka, William MacNee, Martin Connell, John T Murchison, Michael Sproule, Omar Hilmi, Douglas K Miller and Neil C Thomson

    Citation: Translational Respiratory Medicine 2013 1:11

    Content type: Short report

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  20. Acute lung injury and the acute respiratory distress syndrome are major causes of morbidity and mortality in critically ill patients. This review focuses on new developments in definitions, epidemiology, clini...

    Authors: Michael A Matthay, Yuanlin Song, Chunxue Bai and Kirk D Jones

    Citation: Translational Respiratory Medicine 2013 1:10

    Content type: Review

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  21. Medical advances have failed to arrest the growing morbidity and mortality from lung diseases. COPD, lung cancer and pulmonary infections remain leading causes of death. More than any other time in human histo...

    Authors: YC Gary Lee and Grant W Waterer

    Citation: Translational Respiratory Medicine 2013 1:9

    Content type: Editorial

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  22. There is evidence that the potential for high concentration oxygen therapy to increase PaCO2 is not limited to stable and acute exacerbations of COPD, but also to other acute respiratory disorders with abnormal g...

    Authors: Janine Pilcher, Kyle Perrin and Richard Beasley

    Citation: Translational Respiratory Medicine 2013 1:8

    Content type: Editorial

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  23. The link between long-term ICS therapy and respiratory infection in COPD patients is controversial. We investigated the effect of long-term use of inhaled corticosteroid on Toll like receptor 2 (TLR2) expressi...

    Authors: Haixing Zhu, Yuheng Shi, Wei Tang, Guocao Shi and Huanyin Wan

    Citation: Translational Respiratory Medicine 2013 1:7

    Content type: Research

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  24. Lung cancer is a heterogeneous and complex disease. Genomic and transcriptomic profiling of lung cancer not only further our knowledge about cancer initiation and progression, but could also provide guidance o...

    Authors: Susan Y Luo and David CL Lam

    Citation: Translational Respiratory Medicine 2013 1:6

    Content type: Review

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  25. Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals. The aggregati...

    Authors: Qunying Hong, Li-Jin Hsu, Pei-Yi Chou, Ying-Tsen Chou, Chen-Yu Lu, Yu-An Chen and Nan-Shan Chang

    Citation: Translational Respiratory Medicine 2013 1:5

    Content type: Perspective

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  26. The prevalence of asthma has increased over recent decades and the reasons for this are poorly understood. A sensitive tool that can evaluate potential risk factors for asthma is bronchial hyperresponsiveness ...

    Authors: Mark Weatherall, James Fingleton, Sally Eyers and Richard Beasley

    Citation: Translational Respiratory Medicine 2013 1:4

    Content type: Short report

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  27. The effect of smoking on blood viscosity is widely known. There are, however, few studies on the effect of blood viscosity on pulmonary circulation.

    Authors: Gulfidan Cakmak, Fatma Ates Alkan, Kazim Korkmaz, Zuhal Aydan Saglam, Denizhan Karis, Mustafa Yenigun and Meltem Ercan

    Citation: Translational Respiratory Medicine 2013 1:3

    Content type: Research

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  28. Linear polyethylenimine (LPEI) is considered as a desirable gene in vivo delivery system, but whether it could deliver the specific siRNA targeted EGFR to the tumor site to inhibit the growth of NSCLC xenograft i...

    Authors: Pinghai Zhang, Nuo Xu, Lei Zhou, Xin Xu, Yuehong Wang, Ka Li, Zhaochong Zeng, Xiangdong Wang, Xin Zhang and Chunxue Bai

    Citation: Translational Respiratory Medicine 2013 1:2

    Content type: Research

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